Custom Peptides
Cayman Chemical R 715trIfluoroacetAT salt 10mg
A bradykinin B1 receptor antagonist; inhibits bradykinin-induced contractions in isolated human umbilical cords, which express bradykinin B1 receptors (pA2 = 8.49); decreases the latency to tail withdrawal in the tail-flick test in an STZ-induced mouse model of diabetic neuropathy at 200, 400, and 600 UG/kg; reduces the incidence of hind limb weakness and paralysis, improves symmetrical gait, as well as decreases spinal inflammatory foci numbers, neuron demyelination, and lesion monocyte invasion, in a MOG35-55 peptide-induced mouse model of EAE at 1 mg/kg per day; reduces mean arterial blood pressure and increases heart rate in spontaneously hypertensive rats at 0.01 nmol/animal, i.c.v
Cayman Chemical MInoxIdIl-d10 10mg
An internal standard for the quantification of minoxidil by GC- or LC-MS
Cayman Chemical QuInacrIn nalog 34 10mg
An autophagy inhibitor (MEC = 0.5 µM in U2OS cells); induces lysosomal deacidification and accumulation of LC3-II in U2OS cells at 0.5 or 3 µM
Cayman Chemical TrIbulosIdehydrate 10mg
A flavonoid; active against M. madagascariense and M. indicus pranii (MICs = 0.8 and 1.6 mg/ml); scavenges DPPH radicals at 63.7-75.2 mg/ml
Cayman Chemical NorcholIc AcId 10mg
A bile acid and derivative of cholic acid; urine levels are increased in patients with liver cirrhosis or CTX
Cayman Chemical npIcastathydrochlorIde 10mg
An inhibitor of DBH (IC50 = 9 nM for the purified human enzyme); selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC50s or Kis = >10 μM); dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs; attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats at 10 and 30 mg/kg; reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats at 50 mg/kg; reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine, or foot-shock in rats
Cayman Chemical 4-DafachronIc AcId 10mg
A racemic mixture of (25R)-Δ4-dafachronic acid and (25S)-Δ4-dafachronic acid; an agonist of DAF-12; a metabolite of cholesterol in C. elegans; induces transactivation of DAF-12 in NIH3T3 cells expressing the C. elegans or D. immitis receptor (EC50s = 81 and 0.65 nM, respectively); induces molting of infective D. immitis (heartworm) third-stage larvae into L4 larvae; induces the escape trajectory in embryos of the annual killifish A. limnaeus at 25°C at 75 µM
Cayman Chemical 17phenyl trInor Prostglnd 10mg
17-phenyl trinor PGD2 is a novel, chemically stable analog of PGD2 wherein the lower side chain is modified by the addition of a phenyl group at C-17 in place of the last 3 ω-chain carbon atoms. This modification has not been reported in a D-type prostaglandin. However, in the PGE and PGF series, the analogous modification leads to a stable, somewhat more potent agonist which embodies the same biological activities as the parent prostaglandins.
Cayman Chemical SonpIprazole 10mg
A selective D4 receptor antagonist (Kis = 10 nM); selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as α1- and α2-adrenergic receptors (Kis > 2,000 nM)
Cayman Chemical 15-keto ProstaglndIn F1a 10mg
15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins.{1586}
Cayman Chemical GBR 12909hydrochlorIde 10mg
A potent inhibitor that blocks dopamine uptake (IC50 = 1-51 nM); effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors.
Cayman Chemical Hexnoyl GlycIn 10mg
An acylated amino acid that is used as a urinary biomarker for several indications; increased urinary excretion is indicative of MCAD deficiency; can also be used as a biomarker for exposure to gamma radiation
Cayman Chemical AzumolensodIum salt 10mg
A muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum; inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 µM azumolene causing a 70% reduction in SOCE in myotubes